The Darwin Droid has crunched its data and spit out a set of predictions. This week we’ve decided to show our picks before the games. Below are the selected predictions:
| Visitor | Home | Predicted Winner |
| Arizona Cardinals | San Fransisco 49ers | Arizona Cardinals |
| Chicago Bears | Indianapolis Colts | Chicago Bears |
| Houstan Texans | Minnesota Vikings | Minnesota Vikings |
| New England Patriots | Cleveland Browns | Cleveland Browns |
| New York Jets | Pittsburgh Steelers | Pittsburgh Steelers |
| Philadelphia Eagles | Detroit Lions | Detroit Lions |
| Tennessee Titans | Miama Dolphins | Tennessee Titans |
| Washington Redskins | Baltimore Ravens | Baltimore Ravens |
| Atlanta Falcons | Denver Broncos | Atlanta Falcons |
| Buffalo Bills | Los Angeles Rams | Buffalo Bills |
| Cincinnati Bengals | Dallas Cowboys | Dallas Cowboys |
| San Diego Chargers | Oakland Raiders | Oakland Raiders |
| New York Giants | Green Bay Packers | New York Giants |
| Tampa Bay Buccaneers | Carolina Panthers | Carolina Panthers |